Anti Aging Secrets Unlocked in Breakthrough Cellular Dietary Supplement

Anti Aging Secrets Discovered
In Cellular Anti Aging Tonic

Ingredients Support Heart Health, Brain Health,
and Joint Health in Laboratory Studies

Unlocked anti aging secrets reveal that resveratrol—a substance found in red wine—and a muscadine super grape may hold the keys to remarkably prolonged cellular life that helps combat the diseases of aging including arthritis. This breakthrough science is now incorporated in an unprecedented new longevity supplement that has shot to the top of the market.

Launched in August, 2008, this cellular anti-aging dietary supplement has captured the attention of people across America. Developed by the number one natural nutrition company in the U.S., the product is regarded as the world’s best anti aging supplement.

Scientists and the general public have become aware of the compelling research on resveratrol and its ability to extend lifespan in many different laboratory studies. Indeed, resveratrol has been referenced in over 2,500 research citations by the National Library of Medicine, including studies conducted by Harvard University, the National Cancer Institute, and the National Institute on Aging.

For centuries, scientists had been trying to discover the secrets to longer life and better health. New anti aging research reveals that natural substances from the plant world may influence the biological changes related to aging in positive ways at the cellular level including joint health, heart and brain health, cardiovascular function and more.

What anti aging secrets has modern science uncovered?

Science had not cracked anti aging secrets in the past. .The pre-1990 “old view” of aging was simply that the body wears out and there’s nothing you can do about it. Anti aging discoveries by the Anti-Aging Laboratory at Harvard University School of Medicine and other independent scientists have changed that view.

In laboratory studies, anti aging secrets were uncovered that point to the four key mechanisms of cellular aging:

The genesis of the new cellular anti-aging tonic coincided with a landmark research study published in the journal Nature in 2006. This laboratory study surfaced the potential of resveratrol to address two key mechanisms of cellular aging, including improving mitochondrial biogenesis and activating genetic regulators of longevity pathways.

Numerous laboratory studies, including those cited at the end of this page, confirm an effect of resveratrol on helping to protect against a third mechanism of cellular aging, the protection and repair of DNA damage.

New anti aging tonic positively impacts all four key mechanisms of cellular aging

In laboratory studies, the new anti aging tonic fights the four key mechanisms of cellular anti aging and more:

It helps protect and repair cellular DNA
It positively impacts genetic regulators
It promotes mitochondrial biogenesis
It slows Advanced Glycation End Products (AGE) protein formation

In laboratory studies, the product’s ingredients are identified with the following health benefits*:

It supports heart health and cardiovascular function
It supports brain health
It supports immune function
It promotes cellular longevity
It promotes good health and well-being
It supplies antioxidants; fights free radicals
It increases cellular energy

Beyond resveratrol -- anti aging secrets behind the proprietary polyphenol blend

The manufacturer’s scientists went beyond resveratrol in the creation of the new cellular anti aging tonic by creating a unique and patent-pending polyphenol blend that adds to the power of resveratrol. While resveratrol addresses 3 of the four key mechanisms of aging, it is not very effective in addressing the formation of AGE proteins which can compromise cellular integrity and longevity.

The proprietary polyphenol blend includes compounds from the muscadine grape (a so-called super grape because of its size and the fact it’s the only grape found in nature containing an extra chromosome which scientists believe greatly enhances is potential health benefits) that has been shown to be ten times more powerful than resveratrol alone at addressing this 4th mechanism of cellular aging.

In collaboration with scientists from the University of Georgia, the manufacturer’s scientists employed a bioassay-guided process, which resulted in a patent-pending super grape extract with ellagic acid, a polyphenol not found in ordinary grapes. Ellagic acid is thought to be responsible for many of the unique cellular anti-aging actions of the super grape in the new supplement.

In addition, the extract supplies other potent polyphenols affecting cellular longevity pathways, such as phenolic acids, ellagitannins, anthocyanins, and proanthocyanidins.

Included in the discovered secrets of anti aging, scientists identified in laboratory studies that the ingredients found in the new supplement activates genetic regulators of cellular longevity pathways, which may have positive effects on DNA, cellular health, and metabolism.

Secrets behind the supplement’s 98% resveratrol content

In order to create a resveratrol content in a dietary supplement that exceeds anything else on the market the company’s scientists were successful in sourcing the purest and most potent natural resveratrol at a content no less than 98%. This percentage by far exceeds anything on the market today.

In fact, this cellular anti aging tonic is the most complex product ever developed in the 54 year history of the manufacturer because of the challenges for its science team to develop a new extraction process and incorporate it into the production of a highly concentrated and potent liquid formula.

And finally, the manufacturer was able to secure the entire output from the largest and best growers in the world of the muscadine super grape, guaranteeing its exclusivity.

The result is a remarkable dietary supplement with ingredients that have been laboratory tested to address four key mechanisms of cellular aging and the company has filed patents to protect this exclusive and innovative polyphenol formulation.

Secrets of anti-aging uncovered by the featured supplement

The featured cellular anti aging tonic is all-natural, patent-pending and represents breakthroughs in cellular anti aging research that’s absolutely exclusive to the number one natural nutrition company. It has no artificial flavors, colors, sweeteners, or preservatives.

The product is in liquid form and comes in a specially designed bottle that guarantees freshness during shipment. The recommended serving is one teaspoon daily, preferably with a meal (breakfast or lunch is recommended) and delivers 1390 mg of its patent-pending resveratrol blend. Bottles (opened and unopened) should be refrigerated for optimal freshness and quality.

My husband and I have used this product since its introduction in August, 2008 and we believe its improved our joint health, well being and overall energy in remarkable ways. Try a one or two months supply, and decide for yourself.

*Disclaimer: Health statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Citations of key studies that contributed to unlocking anti aging secrets

To help review the science contributed to unlocking anti aging secrets and supporting the manufacturer’s claims, we’ve included the citations of key studies that have been used to validate and support the most important claims made. This includes the manufacturer’s statement that “in laboratory studies the product’s ingredients have been shown to impact four key mechanisms of cellular aging.”

Anti aging secrets: Helps protect and repair cellular DNA

Usha, S., Irudayan, M.J., Mlahi, R., “Interaction of Resveratrol and Genistein with Nucleic Acids”, Journal of Biochemistry and Molecular Biology, Vol 38, No. 2, March 2005, pp. 198-205
Niture, S., Velu, C., Smith, Q., Bhat, J., Srivenugopal, K, “Increased Expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventive natural products in human lymphocytes and tumor lines,”Carcinogenesis, Vol 28, No. 2, pp 378-389, 2007
Yang, S., Irani, K., Heffron, S., Jurnack, F., Meyskens, F., “Alterations in the expressions of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor” Molecular Cancer Therapeutics, 4(12_, December 2005.
Zahid, M., Gaikwad, N.W., Rogan, E.G., Cavalieri, E.L., “Inhibition of depurinating estrogen-DNA adduct formation by natural compounds,” Chemical Research in Toxicology, 20 (12): 1947-53, December 2007
Chakraborty, S., Roy, M., Bhattacharya, R.K., “Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis,” Environmental Pathology, Toxicology, and Oncology, 2004; 23(3): 215-26
Gatz, S.A., Keimling, M., Baumann, C., Dort, T., Debatin, K.M., Fulda, S., Wiesmuller, L., “Resveratrol modulates DNA double-strand break repeair pathways in an ATM/ATR-p53- and –Nbs1-dependent manner”, Carcinogenesis, 2008, Mar; 29(3): 51927. Epub 2008 Jan 3.

Anti aging secrets: Positively impacts genetic regulators

Pearson, K., Baur, J., Lewis, K., Peshkin, L. et al., “Resveratrol Delays Age-Related Deterioration and Mimics Transriptional Aspects of Dietary Restriction without Extending Life Span,” Cell Metabolism, 2008
Barger, J.L., Kayo, T., Pugh, T.D., Prolla, T.A., Weindruch, R., “Short term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart”, Experimental Gerontology, 2008, doi: 10.1016/j.exger.2008.06.013
Barger, J., Kayo, T., Vann, J., Arias, E., Wang, J., Hacker, T., Raederstorff, D., Morrow, J., Leeuwenburgh, C.., Allison, D., Saupe, K., Cartee, G., Weindruch, R., Prolla, T., “A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Paramenters in Mice, “ PLoS ONE, 3(6): e2264, doi:10.1371/journal.pone.0002264
Howitz, K.T. Bitterman, K.J., Cohen, H.Y., Lamming, D.W., Lavu, S., Wood, J.H., Chung, P., Kisielewski, A., Zhang, L.L., Scherer, B., Sinclair, D.A., “Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan”, Nature 2003 nov 11; 425(6954): 191-6. Epub 2003 Aug 24

Anti aging secrets: Promotes mitochondrial biogenesis

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., et al. “Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1a”, Cell, Vol 127, 1109-1122, December 15, 2006
Dasgupta, B., Milbrandt, J., “Resveratrol stimulates AMP kinase activity in neurons”, Proceedings of the National Academy of Sciences, Vol 104, No. 17, April 24, 2007
St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J., Rhee, J., Jager, S., Handschin, C., et al., “Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators”, Cell, Volume 127, 397-408, October 20, 2006
Civitarese, A., Carling, S., Heibronn, L., Hulver, M., Ukropcova, B., Deutsch, W., Smith, S., Ravussin, E., “Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans”, PLoS Medicine, Vol 4, issue 3, March 2007
Lopez-Lluch, G., Irusta, P., Navas, P., deCabo, R., “Mitochondrial biogenesis and healthy aging”, Experimental Gerontology Vol 43, 813-819, 2008

Anti aging secrets: Slows AGE protein formation

Farrar, J., artle, D., Hargrove, J., Greenspan, P., “Inhibition of protein glycation by skins and seeds of the muscadine grape”, BioFactors, Vol 30, 193-200, 2007
Hudson, T., Hartle, D., Hursting, S., Nunez, N., Wang, T., Young, H., Arany, P., Green, J., “Inhibition of Prostate Cancer Growth by Muscadine Grape Skin Extract and Resveratrol through Distinct Mechanisms”, Cancer Research 2007, 6717), September 1, 2007
Bralley, E., Greenspan, P., Hargrove, J., Hartle, D., “Inhibition of Hyarluronidase Activity by Vitas rotundifolia (Muscadine) Berry Seeds and Skins”, Pharmaceutical Biology, Vol 45, No. 9, pp 667-673, 2007
Ramasamy, R., Vannucci, S., Shi Du Tan, S., Herold, K., Yan, S., Schmidt, A., “Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation”, Glycobiology, vol. 15. No. 7 pp. 16R-28R, 2005

Guidance on Resveratrol dosage and Safety

Reagan-Shaw., S., Nihal, M., Ahmad, N., “Dose translation from animal to human studies revisited”, The FASEB Journal, fj.07-9574LSF, published online October 17, 2007
Baur, J., Pearson, K., Price, N., Jamieson, H, Lerin, C., Kalra, A., et al. “Resveratrol improves health and survival of mice on a high calorie diet”, Nature Volume 444, November 16, 2006
Juan, M., Vinardell, M., Planas, J., “The Daily Oral Administration of High Doeses of trans-Resveratrol to Rats for 28 Days is Not Harmful”, The Journal of Nutrition, 132:257-260, 2002
Crowell, J., Korytko, P., Morrissey, R., Boorth, M., Levine, B., “Resveratrol-Associated Renal Toxicity,” Toxicological Sciences, 82, 614-619, 2004
Boocock, D., Faust, G., Patel, K., Schinas, A., Brown, V., Ducharme, M., et al., “Phase 1 Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent”, Cancer Epidemiology Biomarkers & Prevention, 2007, 16(6), June, 2007

Return from Anti aging secrets to Arthritis Relief Naturally Home Page

Health statements have not been evaluated by the Food & Drug Administration.
This site is not intended to diagnose, treat, cure, or prevent any disease.
Copyright 2008 Arthritis-Relief-Naturally.com
Shaklee Authorized Distributor

SBI!


Home Vitamin D & Arthritis Arthritis Supplements Best Fish Oil Pain Relief Creams Arthritis Symptoms Arthritis Treatments Find Best Company Best Supplements Chronic Pain Joint Pain Relief Knee Pain Relief Knee Pain Knee Arthritis Osteoarthritis Rheumatoid Arthritis Best Fish Oil Fish Oil For Arthritis Glucosamine Benefits Anti Aging Frontier Gout Supplements Lupus Supplements Probiotics Are Good 3 Arthritis Products Natural Vitamins Back Pain Herbal Pain Relief Back Arthritis Natural Back Relief Hip Arthritis Hand Arthritis Elbow Pain Relief Arthritis Types Drug Side Effects Adverse Drug Events Natural Pain Relief Natural Stress Relief Anti Aging Secrets Fish Oil Supplements NSAIDs Side Effects Best Glucosamine Best Alfalfa	Anti Aging Secrets Discovered In Cellular Anti Aging Tonic Ingredients Support Heart Health, Brain Health, and Joint Health in Laboratory Studies Unlocked anti aging secrets reveal that resveratrol—a substance found in red wine—and a muscadine super grape may hold the keys to remarkably prolonged cellular life that helps combat the diseases of aging including arthritis. This breakthrough science is now incorporated in an unprecedented new longevity supplement that has shot to the top of the market. Launched in August, 2008, this cellular anti-aging dietary supplement has captured the attention of people across America. Developed by the number one natural nutrition company in the U.S., the product is regarded as the world’s best anti aging supplement. Scientists and the general public have become aware of the compelling research on resveratrol and its ability to extend lifespan in many different laboratory studies. Indeed, resveratrol has been referenced in over 2,500 research citations by the National Library of Medicine, including studies conducted by Harvard University, the National Cancer Institute, and the National Institute on Aging. For centuries, scientists had been trying to discover the secrets to longer life and better health. New anti aging research reveals that natural substances from the plant world may influence the biological changes related to aging in positive ways at the cellular level including joint health, heart and brain health, cardiovascular function and more. What anti aging secrets has modern science uncovered? Science had not cracked anti aging secrets in the past. .The pre-1990 “old view” of aging was simply that the body wears out and there’s nothing you can do about it. Anti aging discoveries by the Anti-Aging Laboratory at Harvard University School of Medicine and other independent scientists have changed that view. In laboratory studies, anti aging secrets were uncovered that point to the four key mechanisms of cellular aging: The genesis of the new cellular anti-aging tonic coincided with a landmark research study published in the journal Nature in 2006. This laboratory study surfaced the potential of resveratrol to address two key mechanisms of cellular aging, including improving mitochondrial biogenesis and activating genetic regulators of longevity pathways. Numerous laboratory studies, including those cited at the end of this page, confirm an effect of resveratrol on helping to protect against a third mechanism of cellular aging, the protection and repair of DNA damage. New anti aging tonic positively impacts all four key mechanisms of cellular aging In laboratory studies, the new anti aging tonic fights the four key mechanisms of cellular anti aging and more: It helps protect and repair cellular DNA It positively impacts genetic regulators It promotes mitochondrial biogenesis It slows Advanced Glycation End Products (AGE) protein formation In laboratory studies, the product’s ingredients are identified with the following health benefits: It supports heart health and cardiovascular function It supports brain health It supports immune function It promotes cellular longevity It promotes good health and well-being It supplies antioxidants; fights free radicals It increases cellular energy Beyond resveratrol -- anti aging secrets behind the proprietary polyphenol blend The manufacturer’s scientists went beyond resveratrol in the creation of the new cellular anti aging tonic by creating a unique and patent-pending polyphenol blend that adds to the power of resveratrol. While resveratrol addresses 3 of the four key mechanisms of aging, it is not very effective in addressing the formation of AGE proteins which can compromise cellular integrity and longevity. The proprietary polyphenol blend includes compounds from the muscadine grape (a so-called super grape because of its size and the fact it’s the only grape found in nature containing an extra chromosome which scientists believe greatly enhances is potential health benefits) that has been shown to be ten times more powerful than resveratrol alone at addressing this 4th mechanism of cellular aging. In collaboration with scientists from the University of Georgia, the manufacturer’s scientists employed a bioassay-guided process, which resulted in a patent-pending super grape extract with ellagic acid, a polyphenol not found in ordinary grapes. Ellagic acid is thought to be responsible for many of the unique cellular anti-aging actions of the super grape in the new supplement. In addition, the extract supplies other potent polyphenols affecting cellular longevity pathways, such as phenolic acids, ellagitannins, anthocyanins, and proanthocyanidins. Included in the discovered secrets of anti aging, scientists identified in laboratory studies that the ingredients found in the new supplement activates genetic regulators of cellular longevity pathways, which may have positive effects on DNA, cellular health, and metabolism. Secrets behind the supplement’s 98% resveratrol content In order to create a resveratrol content in a dietary supplement that exceeds anything else on the market the company’s scientists were successful in sourcing the purest and most potent natural resveratrol at a content no less than 98%. This percentage by far exceeds anything on the market today. In fact, this cellular anti aging tonic is the most complex product ever developed in the 54 year history of the manufacturer because of the challenges for its science team to develop a new extraction process and incorporate it into the production of a highly concentrated and potent liquid formula. And finally, the manufacturer was able to secure the entire output from the largest and best growers in the world of the muscadine super grape, guaranteeing its exclusivity. The result is a remarkable dietary supplement with ingredients that have been laboratory tested to address four key mechanisms of cellular aging and the company has filed patents to protect this exclusive and innovative polyphenol formulation. Secrets of anti-aging uncovered by the featured supplement The featured cellular anti aging tonic is all-natural, patent-pending and represents breakthroughs in cellular anti aging research that’s absolutely exclusive to the number one natural nutrition company. It has no artificial flavors, colors, sweeteners, or preservatives. The product is in liquid form and comes in a specially designed bottle that guarantees freshness during shipment. The recommended serving is one teaspoon daily, preferably with a meal (breakfast or lunch is recommended) and delivers 1390 mg of its patent-pending resveratrol blend. Bottles (opened and unopened) should be refrigerated for optimal freshness and quality. My husband and I have used this product since its introduction in August, 2008 and we believe its improved our joint health, well being and overall energy in remarkable ways. Try a one or two months supply, and decide for yourself. Disclaimer: Health statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Citations of key studies that contributed to unlocking anti aging secrets To help review the science contributed to unlocking anti aging secrets and supporting the manufacturer’s claims, we’ve included the citations of key studies that have been used to validate and support the most important claims made. This includes the manufacturer’s statement that “in laboratory studies the product’s ingredients have been shown to impact four key mechanisms of cellular aging.” Anti aging secrets: Helps protect and repair cellular DNA Usha, S., Irudayan, M.J., Mlahi, R., “Interaction of Resveratrol and Genistein with Nucleic Acids”, Journal of Biochemistry and Molecular Biology, Vol 38, No. 2, March 2005, pp. 198-205 Niture, S., Velu, C., Smith, Q., Bhat, J., Srivenugopal, K, “Increased Expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventive natural products in human lymphocytes and tumor lines,”Carcinogenesis, Vol 28, No. 2, pp 378-389, 2007 Yang, S., Irani, K., Heffron, S., Jurnack, F., Meyskens, F., “Alterations in the expressions of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor” Molecular Cancer Therapeutics, 4(12_, December 2005. Zahid, M., Gaikwad, N.W., Rogan, E.G., Cavalieri, E.L., “Inhibition of depurinating estrogen-DNA adduct formation by natural compounds,” Chemical Research in Toxicology, 20 (12): 1947-53, December 2007 Chakraborty, S., Roy, M., Bhattacharya, R.K., “Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis,” Environmental Pathology, Toxicology, and Oncology, 2004; 23(3): 215-26 Gatz, S.A., Keimling, M., Baumann, C., Dort, T., Debatin, K.M., Fulda, S., Wiesmuller, L., “Resveratrol modulates DNA double-strand break repeair pathways in an ATM/ATR-p53- and –Nbs1-dependent manner”, Carcinogenesis, 2008, Mar; 29(3): 51927. Epub 2008 Jan 3. Anti aging secrets: Positively impacts genetic regulators Pearson, K., Baur, J., Lewis, K., Peshkin, L. et al., “Resveratrol Delays Age-Related Deterioration and Mimics Transriptional Aspects of Dietary Restriction without Extending Life Span,” Cell Metabolism, 2008 Barger, J.L., Kayo, T., Pugh, T.D., Prolla, T.A., Weindruch, R., “Short term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart”, Experimental Gerontology, 2008, doi: 10.1016/j.exger.2008.06.013 Barger, J., Kayo, T., Vann, J., Arias, E., Wang, J., Hacker, T., Raederstorff, D., Morrow, J., Leeuwenburgh, C.., Allison, D., Saupe, K., Cartee, G., Weindruch, R., Prolla, T., “A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Paramenters in Mice, “ PLoS ONE, 3(6): e2264, doi:10.1371/journal.pone.0002264 Howitz, K.T. Bitterman, K.J., Cohen, H.Y., Lamming, D.W., Lavu, S., Wood, J.H., Chung, P., Kisielewski, A., Zhang, L.L., Scherer, B., Sinclair, D.A., “Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan”, Nature 2003 nov 11; 425(6954): 191-6. Epub 2003 Aug 24 Anti aging secrets: Promotes mitochondrial biogenesis Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., et al. “Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1a”, Cell, Vol 127, 1109-1122, December 15, 2006 Dasgupta, B., Milbrandt, J., “Resveratrol stimulates AMP kinase activity in neurons”, Proceedings of the National Academy of Sciences, Vol 104, No. 17, April 24, 2007 St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J., Rhee, J., Jager, S., Handschin, C., et al., “Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators”, Cell, Volume 127, 397-408, October 20, 2006 Civitarese, A., Carling, S., Heibronn, L., Hulver, M., Ukropcova, B., Deutsch, W., Smith, S., Ravussin, E., “Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans”, PLoS Medicine, Vol 4, issue 3, March 2007 Lopez-Lluch, G., Irusta, P., Navas, P., deCabo, R., “Mitochondrial biogenesis and healthy aging”, Experimental Gerontology Vol 43, 813-819, 2008 Anti aging secrets: Slows AGE protein formation Farrar, J., artle, D., Hargrove, J., Greenspan, P., “Inhibition of protein glycation by skins and seeds of the muscadine grape”, BioFactors, Vol 30, 193-200, 2007 Hudson, T., Hartle, D., Hursting, S., Nunez, N., Wang, T., Young, H., Arany, P., Green, J., “Inhibition of Prostate Cancer Growth by Muscadine Grape Skin Extract and Resveratrol through Distinct Mechanisms”, Cancer Research 2007, 6717), September 1, 2007 Bralley, E., Greenspan, P., Hargrove, J., Hartle, D., “Inhibition of Hyarluronidase Activity by Vitas rotundifolia (Muscadine) Berry Seeds and Skins”, Pharmaceutical Biology, Vol 45, No. 9, pp 667-673, 2007 Ramasamy, R., Vannucci, S., Shi Du Tan, S., Herold, K., Yan, S., Schmidt, A., “Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation”, Glycobiology, vol. 15. No. 7 pp. 16R-28R, 2005 Guidance on Resveratrol dosage and Safety Reagan-Shaw., S., Nihal, M., Ahmad, N., “Dose translation from animal to human studies revisited”, The FASEB Journal, fj.07-9574LSF, published online October 17, 2007 Baur, J., Pearson, K., Price, N., Jamieson, H, Lerin, C., Kalra, A., et al. “Resveratrol improves health and survival of mice on a high calorie diet”, Nature Volume 444, November 16, 2006 Juan, M., Vinardell, M., Planas, J., “The Daily Oral Administration of High Doeses of trans-Resveratrol to Rats for 28 Days is Not Harmful”, The Journal of Nutrition, 132:257-260, 2002 Crowell, J., Korytko, P., Morrissey, R., Boorth, M., Levine, B., “Resveratrol-Associated Renal Toxicity,” Toxicological Sciences, 82, 614-619, 2004 Boocock, D., Faust, G., Patel, K., Schinas, A., Brown, V., Ducharme, M., et al., “Phase 1 Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent”, Cancer Epidemiology Biomarkers & Prevention, 2007, 16(6), June, 2007 Return from Anti aging secrets to Arthritis Relief Naturally Home Page Health statements have not been evaluated by the Food & Drug Administration. This site is not intended to diagnose, treat, cure, or prevent any disease. Copyright 2008 Arthritis-Relief-Naturally.com Shaklee Authorized Distributor SBI!

Anti Aging Secrets Discovered In Cellular Anti Aging Tonic